Xanthine Oxidoreductase Is Involved in Chondrocyte Mineralization and Expressed in Osteoarthritic Damaged Cartilage

Chondrocyte multiplication in osteoarthritic articular cartilage.

Modulating chondrocyte hypertrophy in growth plate and osteoarthritic cartilage.

induce expression of active proteinases leading to increased matrix degradation. Other fragments increase matrix synthesis and cellular proliferation. Several studies have suggested that type II collagen fragments might influence chondrocyte differentiation in endochondral ossification, and we hypothesise that collagen II fragments might also promote cellular hypertrophy when they are over-prod...

Cartilage in osteoarthritic joints is not automatically osteoarthritic cartilage.

Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development.

OBJECTIVE Hyperuricemia is common in patients with metabolic syndrome. We investigated the role of xanthine oxidoreductase (XOR) in atherosclerosis development, and the effects of the XOR inhibitor allopurinol on this process. METHODS AND RESULTS Oral administration of allopurinol to ApoE knockout mice markedly ameliorated lipid accumulation and calcification in the aorta and aortic root. In ...

The Expression of Signal Regulatory Protein-alpha in Normal and Osteoarthritic Human Articular Cartilage and Its Involvement in Chondrocyte Mechano-transduction Response

Signal regulatory proteins (SIRP) belong to immunoglobulin super family (IgSF) and relate to integrin signaling cascades. It has been shown that SIRPa is expressed in a variety of cells including myeloid cells and neurons. In the present study the expression of this IgSF member in articular chondrocytes was investigated. Methods: Using a panel of anti-SIRPalpha antibodies, immunohistochemistry...